Baked Pesto Chicken Mac & Cheese

Featured in: Hearty Comfort Food

This comforting casserole combines tender pesto-marinated chicken pieces with homemade creamy cheese sauce and perfectly cooked macaroni. The dish gets crowned with crispy parmesan and panko crumbs mixed with more pesto for irresistible crunch. After 25 minutes of prep and a quick bake, you'll have a bubbling, golden masterpiece that serves six.

Updated on Sun, 08 Feb 2026 19:44:33 GMT
Golden brown Baked Pesto Chicken Mac & Cheese with crispy parmesan crumbs pulled from a casserole dish with a serving spoon. Save
Golden brown Baked Pesto Chicken Mac & Cheese with crispy parmesan crumbs pulled from a casserole dish with a serving spoon. | dashnosh.com

Experience the ultimate fusion of comfort and zest with this Baked Pesto Chicken Mac & Cheese. This dish takes the classic, creamy mac and cheese you love and elevates it with tender, pesto-marinated chicken and a sophisticated Italian flair. It is a hearty, bubbly casserole topped with a crisp, golden parmesan crumb that makes every bite a perfect balance of textures.

Golden brown Baked Pesto Chicken Mac & Cheese with crispy parmesan crumbs pulled from a casserole dish with a serving spoon. Save
Golden brown Baked Pesto Chicken Mac & Cheese with crispy parmesan crumbs pulled from a casserole dish with a serving spoon. | dashnosh.com

The secret to this dish is the marinated chicken, which ensures every morsel is infused with basil and garlic. As it bakes in the oven, the cheddar and mozzarella melt into a velvety sauce that perfectly coats the elbow macaroni, creating a meal that is as visually stunning as it is delicious.

Ingredients

  • Pasta: 400 g (14 oz) elbow macaroni or short pasta
  • Chicken & Marinade: 2 large boneless, skinless chicken breasts (about 400 g/14 oz), 3 tbsp basil pesto, 1 tbsp olive oil, 1/2 tsp salt, 1/4 tsp black pepper
  • Cheese Sauce: 3 tbsp unsalted butter, 3 tbsp all-purpose flour, 2 cups (480 ml) whole milk (warmed), 1 cup (240 ml) heavy cream, 2 cups (200 g) shredded sharp cheddar cheese, 1 cup (90 g) grated mozzarella cheese, 1/2 cup (50 g) grated parmesan cheese, 1/2 tsp garlic powder, 1/4 tsp ground nutmeg, salt and pepper to taste
  • Topping: 1 cup (100 g) panko breadcrumbs, 2 tbsp melted butter, 1/4 cup (25 g) grated parmesan cheese, 2 tbsp basil pesto
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Instructions

Step 1
Preheat oven to 200°C (400°F). Grease a 23x33 cm (9x13-inch) baking dish.
Step 2
Cook the pasta in salted boiling water 2 minutes less than package instructions (it will finish in the oven). Drain and set aside.
Step 3
While pasta cooks, butterfly the chicken breasts and cut into bite-sized pieces. Toss with 3 tbsp pesto, olive oil, salt, and pepper. Let marinate 10 minutes.
Step 4
In a large skillet over medium-high heat, sear the chicken pieces until just cooked through, about 5–6 minutes. Remove from heat.
Step 5
For the cheese sauce, melt butter in a large saucepan over medium heat. Whisk in flour and cook 1 minute. Gradually whisk in milk and cream. Stir constantly until slightly thickened, about 3–4 minutes.
Step 6
Lower heat and stir in cheddar, mozzarella, and parmesan cheeses until melted and smooth. Add garlic powder, nutmeg, salt, and pepper. Remove from heat.
Step 7
Combine the cooked pasta, cheese sauce, and pesto chicken in a large bowl. Mix gently to combine.
Step 8
Pour mixture into prepared baking dish.
Step 9
In a small bowl, mix panko, melted butter, parmesan, and pesto for the topping. Sprinkle evenly over the casserole.
Step 10
Bake 20–25 minutes, until topping is golden and casserole is bubbling. Let rest 5–10 minutes before serving.

Zusatztipps für die Zubereitung

To achieve a silky cheese sauce, ensure you whisk the warmed milk and cream into the flour and butter mixture gradually. This prevents lumps from forming. Additionally, undercooking the pasta by two minutes is vital; it allows the noodles to absorb the cheese sauce while baking without becoming over-soft.

Varianten und Anpassungen

If you are short on time, you can substitute the seared chicken with a rotisserie chicken—simply shred it and toss with pesto before adding it to the pasta. For a different flavor profile, consider swapping the sharp cheddar for smoked gouda or fontina cheese to add a deeper, creamier complexity to the sauce.

Serviervorschläge

This rich and flavorful mac and cheese pairs beautifully with a crisp green side salad to provide a fresh contrast. For a complete dining experience, serve it with a chilled glass of Sauvignon Blanc, which complements the herbal notes of the basil pesto perfectly.

A close up of Baked Pesto Chicken Mac & Cheese featuring tender marinated chicken pieces and creamy cheddar sauce in pasta. Save
A close up of Baked Pesto Chicken Mac & Cheese featuring tender marinated chicken pieces and creamy cheddar sauce in pasta. | dashnosh.com

This Baked Pesto Chicken Mac & Cheese is a soul-warming dish that brings together the best of two worlds. Each serving contains approximately 670 calories, 36 g of fat, 49 g of carbohydrates, and 39 g of protein, making it a satisfying and complete main dish for any night of the week.

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Kitchen Q&A

Can I make this ahead of time?

Yes, assemble everything up to 24 hours ahead, cover tightly, and refrigerate. Add an extra 10-15 minutes to baking time since it will be cold.

What pasta shapes work best?

Elbow macaroni is classic, but cavatappi, penne, or shells all catch the cheese sauce beautifully. Choose short pasta with nooks and crannies.

Can I use rotisserie chicken?

Absolutely. Skip the marinating and searing steps. Just shred rotisserie chicken and toss with pesto before combining with pasta and cheese sauce.

How do I store leftovers?

Keep in an airtight container in the refrigerator for 3-4 days. Reheat individual portions in the microwave, or cover the whole dish with foil and warm at 180°C (350°F) until heated through.

Can I freeze this?

You can freeze the unbaked casserole for up to 3 months. Thaw overnight in the refrigerator before baking as directed, adding extra time if still cold in the center.

Baked Pesto Chicken Mac & Cheese

Tender pesto chicken meets bubbly mac and cheese with crispy parmesan breadcrumb topping.

Prep Duration
25 min
Cook Duration
35 min
Complete Duration
60 min
Created by Tyler Morgan

Recipe Type Hearty Comfort Food

Skill Level Medium

Cultural Heritage Italian-American

Output 6 Portion Size

Nutritional Categories None specified

What You'll Need

Pasta

01 14 oz elbow macaroni or short pasta

Chicken & Marinade

01 2 large boneless, skinless chicken breasts, about 14 oz total
02 3 tablespoons basil pesto
03 1 tablespoon olive oil
04 1/2 teaspoon salt
05 1/4 teaspoon black pepper

Cheese Sauce

01 3 tablespoons unsalted butter
02 3 tablespoons all-purpose flour
03 2 cups whole milk, warmed
04 1 cup heavy cream
05 2 cups shredded sharp cheddar cheese
06 1 cup grated mozzarella cheese
07 1/2 cup grated parmesan cheese
08 1/2 teaspoon garlic powder
09 1/4 teaspoon ground nutmeg
10 Salt and pepper to taste

Topping

01 1 cup panko breadcrumbs
02 2 tablespoons melted butter
03 1/4 cup grated parmesan cheese
04 2 tablespoons basil pesto

Method

Step 01

Prepare the oven and baking dish: Preheat oven to 400°F. Grease a 9x13-inch baking dish with butter or cooking spray.

Step 02

Parboil the pasta: Cook pasta in salted boiling water for 2 minutes less than package instructions, as it will finish cooking in the oven. Drain and set aside.

Step 03

Marinate the chicken: Butterfly the chicken breasts and cut into bite-sized pieces. Toss with 3 tablespoons pesto, 1 tablespoon olive oil, 1/2 teaspoon salt, and 1/4 teaspoon black pepper. Let marinate for 10 minutes.

Step 04

Sear the chicken: Heat a large skillet over medium-high heat. Sear the marinated chicken pieces until just cooked through, about 5 to 6 minutes. Remove from heat and set aside.

Step 05

Create the cheese sauce: Melt 3 tablespoons butter in a large saucepan over medium heat. Whisk in 3 tablespoons flour and cook for 1 minute. Gradually whisk in 2 cups warm milk and 1 cup heavy cream, stirring constantly until slightly thickened, about 3 to 4 minutes.

Step 06

Combine cheeses and seasonings: Lower heat and stir in 2 cups cheddar cheese, 1 cup mozzarella cheese, and 1/2 cup parmesan cheese until melted and smooth. Add 1/2 teaspoon garlic powder, 1/4 teaspoon nutmeg, salt, and pepper to taste. Remove from heat.

Step 07

Assemble the casserole: Combine the cooked pasta, cheese sauce, and pesto chicken in a large mixing bowl. Gently fold together until evenly coated.

Step 08

Transfer to baking dish: Pour the combined mixture into the prepared 9x13-inch baking dish and spread evenly.

Step 09

Prepare the topping: In a small bowl, mix 1 cup panko breadcrumbs, 2 tablespoons melted butter, 1/4 cup parmesan cheese, and 2 tablespoons pesto. Sprinkle evenly over the casserole.

Step 10

Bake and rest: Bake at 400°F for 20 to 25 minutes, until the topping is golden brown and the casserole is bubbling at the edges. Remove from oven and let rest for 5 to 10 minutes before serving.

Kitchen Tools Needed

  • Large pot for cooking pasta
  • Large skillet for searing chicken
  • Large saucepan for cheese sauce
  • Whisk for blending sauce
  • 9x13-inch baking dish
  • Mixing bowls

Allergy Alerts

Review ingredients carefully for potential allergens and seek professional medical guidance if concerned.
  • Contains wheat gluten from pasta and breadcrumbs
  • Contains dairy including milk, cream, butter, and three varieties of cheese
  • Contains tree nuts from basil pesto
  • May contain eggs in pasta and breadcrumbs
  • Contains poultry

Nutrition Details (serving size)

Numbers shown are estimates only - consult healthcare providers for specific advice.
  • Energy: 670
  • Fats: 36 g
  • Carbohydrates: 49 g
  • Proteins: 39 g